What is Semaglutide?
Semaglutide is a modified molecule our bodies make, called a GLP-1 analog. It works by increasing insulin production and lowers glucagon secretion as well as targets areas in the brain that regulate appetite and food intake. A small change in the molecule allows the drug to last weeks in our bodies rather than the natural version our bodies make, which lasts minutes. Originally used for diabetes and sold under the name Ozempic®. In June 2021, Wegovy, brand name Semaglutide, was FDA approved for weight loss.
How Does Semaglutide Work?
Semaglutide acts in the following ways:
• Delays how quickly our stomachs digest food, leading to a feeling of fullness and satisfaction with smaller meal sizes.
• Slows intestinal motility so you will feel fuller longer after meals.
• Lowers blood sugars, in part by reducing the production of sugar in the liver.
• Stimulates insulin secretion by the pancreas.
Benefits of Semaglutide
• Decreased appetite and cravings
• Weight loss
• Improved blood glucose control
The most common side effects include nausea and constipation. * Patients also report acid reflux, stomach pain, vomiting, and diarrhea. The risk of serious side effects increases in patients with hypoglycemia, kidney problems, and risk of allergic reactions.
*1mg/mL of Cyanocobalamin added to reduce nausea side effects.
To prevent side effects, one must avoid fatty food and spicy food.
- **This medication is not insulin and should not be used if you have type 1 diabetes or if you develop diabetic ketoacidosis. Semaglutide should not be used with any other GLP-1 medications ie (Dulaglutide (Trulicity)
- Exenatide extended release (Bydureon bcise)
- Exenatide (Byetta) , Semaglutide (Ozempic) , Liraglutide (Victoza, Saxenda)
RISK OF THYROID C−CELL TUMORS. If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take Semaglutide. If you have ever had pancreatitis consult with your medical provider as using Semaglutide can increase the risk of developing pancreatitis.